as well, pls share Wireguard Server config file.
And one more to share
ls -l /etc/alternatives/iptables
Maybe it is similar to the issue we had on Odroid. Just thinking 
https://dietpi.com/forum/t/wireguard-connection-is-not-working-on-odroid-bullseye/6180/20
Did you tried to reboot your system in between?