Figured it out.
Not sure with Proftpd, but with samba server, you can add additional shares in /etc/samba/smb.conf:
[drive2]
comment = DietPi Share 2
path = /mnt/location_to_drive2
browseable = yes
create mask = 0775
directory mask = 0775
valid users = root
writeable = yes
Can samba and proftpd run at the same time?
Yep, you can install both through DietPi-Software. Set Fileserver choice to none/manual, Go start install.
After reboot select ProFTP and Samba server from the DietPi optimized software list ( ────File Servers at bottom). Go start install